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CD244 Mouse anti-Human, FITC, Clone: eBioDM244, eBioscience™

Mouse Monoclonal Antibody

£65.75 - £132.00

Specifications

Antigen CD244
Clone eBioDM244
Target Species Human
Conjugate FITC
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15596566
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Affymetrix eBioscience
11-5837-41
25 Tests £65.75
25 tests View alternative products
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Estimated Shipment
30-11-2020
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15506576
View Documents
Affymetrix eBioscience
11-5837-42
100 Tests £132.00
100 tests View alternative products
Save Up to 
»
Estimated Shipment
30-11-2020
Please to purchase this item. Need a web account? Register with us today!
Description

Description

CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
Specifications

Specifications

CD244
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
eBioDM244
FITC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.