CD244 Mouse anti-Human, Biotin, Clone: eBioC1.7 (C1.7), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-5838-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15289869

Quantity Price
1 £ 42.19 / 50µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Antigen CD244
Host Species Mouse
Isotype IgG1
Quantity 50μg
Format Conjugated
Clone eBioC1.7 (C1.7)
Conjugate Biotin
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias 2B4, p38, SLAMF4
Species Reactivity Human
Applications Flow Cytometry
Primary or Secondary Primary
Concentration 0.5mg/mL
Storage Requirements Store at 2-8°C. Do not freeze.

The eBioC1.7 monoclonal antibody reacts with human CD244 (2B4, p38). In human, CD244 is a 38kDa protein expressed on NK cells, a subset of CD8+ T cells, γδ T cells, monocytes, basophils and eosinophils. Binding of the CD244 ligand, CD48, results in NK cell activation, unlike mouse CD244, which is an inhibitory receptor. For CD244 expressed on NK cells, binding of CD48 results in enhanced NK cell cytotoxicity and secretion of IFN-γ. Recently, it was demonstrated that binding of the C1.7 monoclonal antibody and CD48 involve the same residue in the V domain of human CD244, which explains the ability of C1.7 binding to induce activation of NK cells. Binding of C1.7 to CD244 leads to tyrosine phosphorylation and recruitment of the adaptor molecule SAP (SLAM-associated protein). Patients with X-linked lymphoproliferative disorder (XLPD) have a mutation in SAP which renders it unable to bind to phosphorylated CD244.