CD227 (Mucin-1) Mouse anti-Human, Clone: SM3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9893-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15218217

Quantity Price
1 £ 152.25 / 100µg
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Applications Immunocytochemistry
Applications Immunohistochemistry
Applications Western Blotting
Format Purified
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Gene Alias Mucin Glycoprotein, MUC1, EMA (Epithelial Membrane Antigen), Episialin, Tumor-Associated Mucin, PEM (Polymorphic Epithelial Mucin), Breast Cancer-Associated Antigen
Conjugate Unlabeled
Host Species Mouse
Clone SM3
Isotype IgG1
Concentration 0.5mg/mL
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Regulatory Status RUO
Quantity 100μg
Storage Requirements Store at 2-8°C.
Antigen CD227 (Mucin-1)

This SM3 monoclonal antibody reacts with the under-glycosylated form of human Mucin 1 (MUC1, CD227), a large glycoprotein belonging to the mucin protein family. Mucin 1 contains a polypeptide core consisting of multiple tandem repeats that become highly glycosylated. Mucin 1 is typically expressed in ductal or glandular epithelial cells and is localized to the apical membrane. In cancerous cells, Mucin 1 expression is increased and membrane-specific localization is lost resulting in expression throughout the membrane and cytoplasm. High levels of under-glycosylated Mucin 1 are thought to affect cell behavior during both invasion and metastasis as well as in immune recognition. In addition, under-glycosylated Mucin 1 is shed from the epithelial cell surface and can be detected in circulation. Alterations in Mucin 1 glycosylation are found in most adenocarcinomas of the breast, lung, pancreas, prostate, and ovary. Mucin 1 has recently been shown to co-localize and interact with members of the erbB receptor kinase family, proteins that are upregulated in more aggressive forms of breast cancer.
Please note this antibody sees a distinct epitope from other Mucin 1 antibodies.