CD226 (DNAM-1) Rat anti-Mouse, APC, Clone: 10E5, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-2261-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15360710

Quantity Price
1 £ 188.93 / 100µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Antigen CD226 (DNAM-1)
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Regulatory Status RUO
Primary or Secondary Primary
Species Reactivity Mouse
Clone 1.00E+06
Monoclonal or Polyclonal Monoclonal
Host Species Rat
Conjugate APC
Quantity 100μg
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias DNAM1, PTA1, Tlisa
Concentration 0.2mg/mL
Isotype IgG2b
Format Conjugated

This 10E5 monoclonal antibody reacts with mouse CD226, which is also known as DNAX accessory molecule-1 (DNAM-1). CD226 is an adhesion molecule expressed primarily on T cells, including thymocytes. The highest levels of CD226 are found on naïve CD8 T cells. Moreover, expression of CD226 is regulated differentially in CD4 T cells. Under certain culture conditions, CD226 can be upregulated in Th1 and downregulated in Th2 and Th0 cells. This cell surface receptor can also be detected on natural killer cells, some B cell subsets, monocytes, and platelets. Interaction with its ligands, the poliovirus receptor (CD155) and CD112, results in adhesion and cell signaling events that promote innate and adaptive immunity, including differentiation, survival, and cytotoxicity.

The 10E5 monoclonal antibody has been reported to inhibit antigen-specific T cell proliferation and IFN-gamma production in vivo.