CD22 Mouse, anti-Human, PE, Clone: HIB22, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60083PE

Product Code. 17198931

Description

• The HIB22 antibody reacts with CD22 (Siglec-2), a type I transmembrane glycoprotein expressed in the cytoplasm of pro-B and pre-B cells and on the surface of mature and activated B cells and B cell lymphomas, but not on plasma cells
• CD22 functions as an inhibitory receptor for B cell receptor signaling and plays roles in modulating the activation threshold of B cells and controlling CD40 signaling
• CD22 comprises two isoforms generated by alternative splicing: CD22α (∼130 kDa) and CD22β (∼140 kDa)
• Monomeric CD22β is the most abundant isoform but an αβ heterodimer is also expressed
• CD22 is a member of the sialoadhesion subgroup within the immunoglobulin superfamily, with an N-terminal V-type Ig domain followed by six C2-type Ig domains
• Binding of the HIB22 antibody reportedly requires the presence of the two N-terminal-most domains
• Both the cytoplasmic and surface-bound forms of CD22 are recognized by the HIB22 antibody and its binding does not inhibit CD22-mediated cyto-adhesion

Specifications

• Antigen: CD22
• Classification: Monoclonal
• Conjugate: PE
• Quantity: 100 Tests
• Target Species: Chimpanzee, Human
• Cell Type: B Cells

• Applications: Immunohistochemistry, ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Clone: HIB22
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG1 κ