CD22 Mouse anti-Human, PE, Clone: eBio4KB128 (4KB128), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-0229-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15516736

Quantity Price
1 £ 60.53 / 25 tests
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Host Species Murine
Quantity 25 Tests
Monoclonal or Polyclonal Monoclonal
Isotype IgG1
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen CD22
Concentration 5μL (0.125μg)/test
Format Conjugated
Applications Flow Cytometry
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Clone eBio4KB128 (4KB128)
Conjugate PE
Gene Alias Sialic Acid-Binding Immunoglobulin-Like Lectin 2, SIGLEC2

The eBio4KB128 monoclonal antibody recognizes human CD22 (Siglec-2), which is a member of the siglec subgroup of the Ig superfamily. CD22 is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22α and CD22β, of 130 and 140kDa respectively, produced by alternative splicing of the CD22 gene. CD22 is expressed at high levels on mature B cells and B cell lymphomas. The extracellular portion of CD22 contains seven Ig-like domains, some of which are capable of binding ligands with sialic acid moieties expressed on epithelial, endothelial, B and T cells. The intracellular portion of CD22 contains 6 tyrosine residues contained within immunotyrosine-based inhibitory motifs (ITIM) and immunotyrosine-based activation-like motifs, which are phosphorylated upon B-cell receptor engagement, which enables CD22 to participate in the positive and negative regulation of B-cell receptor signaling.