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CD218a (IL-18 Receptor alpha) Rat anti-Mouse, PerCP-eFluor 710, Clone: P3TUNYA, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-5183-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15549266

  • £87.96 / 25µg


Estimated Shipment date
from Supplier 30-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

This P3TUNYA monoclonal antibody reacts with mouse CD218a (Interleukin 18 Receptor alpha). CD218a is one of the subunits of the heterodimeric receptor complex for the IL-18 cytokine. IL-18 is a proinflammatory cytokine and member of the IL-1 family first identified by its role in IFN gamma secretion during toxic shock. Like the other members of the family, it is synthesized as an inactive precursor which requires cleavage by caspases prior to secretion of the active form. It is secreted by activated monocytes, macrophages, epithelial cells, and keratinocytes via a non-classical pathway.

IL-18 Receptor is expressed on Th1, but not naïve CD4 T cells or Th2, as well as subsets of NK cells and neutrophils. The heterodimeric receptor is made up of a ligand-binding alpha chain and signal-transducing beta chain. On its own, IL-18Ra binds IL-18 with low affinity, although the affinity of this interaction increases upon forming a complex with IL-18Rb. IL-18R signaling plays a critical role in Th1 differentiation and effector function, and results in the increased expression of IFN gamma, TNF alpha, and Fas ligand from T cells and NK cells. IL-18 has also been found to synergize with IL-23 in the development and function of Th17 cells. Recently, a subset of CD8 T cells has been discovered that co-secretes IFN gamma with IL-17A and sometimes IL-22. These Tc17 cells share key transcription factors, chemokine receptors, and cytokine receptors with Th17 cells. In humans, this population has been identified by expression of CD161 and IL-18R. As a CD161 homolog has yet to be identified in mice, it has been suggested that IL-18R may be used as a surrogate for CD161 in mouse Tc17 phenotyping.
Specifications

Specifications

CD218a (IL-18 Receptor alpha)
P3TUNYA
PerCP-eFluor 710
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IL-1RP, IL-1R5, CD218
IgG2a
RUO
Primary
Murine