missing translation for 'onlineSavingsMsg'
Learn More

CD215 (IL-15 Receptor alpha) Mouse anti-Human, Clone: eBioJM7A4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-7159-82

Code : Z2

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15288027

  • £91.11 / 100µg


Estimated Shipment
30-11-2017
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

The eBioJM7A4 monoclonal antibody reacts with the IL-15 receptor alpha chain (IL-15Rα). IL-15 and IL-2 are cytokines with overlapping, but distinct, biologic effects. Their receptors share 2 subunits, the IL-2Rβ and γ chains, which are essential for signal transduction. The IL-15Rα receptor is structurally related to IL-2Rα. However, the IL-15Rα alone binds IL-15 with a 1,000-fold higher affinity than that seen with IL-2Rα and IL-2. In the human, 3 differentially spliced human IL-15Rα variants that are all capable of high affinity binding of IL-15 have been isolated. The cytoplasmic domain of IL-15Rα, like that of IL-2Rα, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding. At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL-2Rβ and IL-2Rγ in the absence of the alpha subunit.
Specifications

Specifications

CD215 (IL-15 Receptor alpha)
eBioJM7A4
Unlabeled
Purified
Murine
100μg
Store at 2-8°C.
Monoclonal
Western Blot
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Interleukin-15 Receptor alpha, IL-15R, IL15R
IgG2b
RUO
Primary
Human