Invitrogen™ CD210 (IL-10R) Monoclonal Antibody (1B1.3a), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Brand:  Invitrogen™ 16-2101-85

Product Code. 15527786

Description

Description: The 1B1.3A monoclonal antibody reacts with mouse CD210, which is also known as the IL-10 receptor. CD210 is a member of the interferon receptor-like family that is expressed on a variety of hematopoietic cells, including thymocytes, T cells, B cells, NK cells, monocytes, and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that leads to B cell proliferation and inhibition of macrophage activation. The 1B1.3A antibody has been reported to have neutralizing activity. Applications Reported: The 1B1.3A antibody has been reported for use in functional assays. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

Specifications

• Antigen: CD210 (IL-10R)
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.2
• Gene Accession No.: Q61727
• Gene Symbols: Il10ra
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16154
• Content And Storage: 4°C
• Form: Liquid

• Applications: Functional Assay
• Clone: 1B1.3a
• Conjugate: Functional Grade
• Gene: Il10ra
• Gene Alias: AW553859; CD210; CD210a; CDw210; CDW210A; CDW210B; CRF2-4; CRFB4; D21S58; D21S66; HIL-10R; I10R; I10R1; il-10 receptor; il-10 receptor antagonist; IL-10 receptor subunit alpha; IL10R; IL-10R alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10R2; Il10ra; IL-10RA; interleukin 10 receptor subunit alpha; interleukin 10 receptor, alpha; interleukin-10 receptor alpha chain; interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha; mIL-10R
• Host Species: Rat
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG1