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Invitrogen™ CD21 Polyclonal Antibody
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Product Code. 16559871
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Quantity:
100 μL
Unit Size:
100µL
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16559871 100 μL 100µL
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Product Code. 16559871 Supplier Invitrogen™ Supplier No. PA597039

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IVTYTCDPDP EEGVNFILIG ESTLRCTVDS QKTGTWSGPA PRCELSTSAV QCPHPQILRG RMVSGQKDRY TYNDTVIFAC MFGFTLKGSK QIRCNAQGTW EPSAPVCEKE CQAPPNILNG QKEDRHMVRF DPGTSIKYSC NPGYVLVGEE SIQCTSEGVW TPPVPQCKVA ACEATGRQLL TKPQHQFVRP DVNSSCGEGY KLSGSVYQEC QGTIPWFMEI RLCKEITCPP PPVIYNGAHT GSSLEDFPYG TTVTYTCNPG PERGVEFSLI GESTIRCTSN DQERGTWSGP A; Positive Samples: B-cell, 293T, Jurkat, Mouse spleen, Mouse liver, Rat liver; Cellular Location: Membrane, Single-pass type I membrane protein.

CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to follicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands. CD21 functions as receptor for C3d, C3dg and iC3b complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively, spliced transcript variants encoding different isoforms of CD21 have been found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD21
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.61 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CR2
Gene Accession No. P19070, P20023
Gene Alias C3b/C4b receptor; C3-binding protein; C3BR; C3DR; C4BR; CD21; CD35; CD35 antigen; cell surface receptor for C3d; complement C3b/C4b receptor 1 (Knops blood group); complement C3d receptor; Complement C3d receptor (C3DR); complement C3d receptor 2; complement component (3b/4b) receptor 1 (Knops blood group); complement component (3d/Epstein Barr virus) receptor 2; complement component 3b/4b receptor 1 (Knops blood group); complement component 3d receptor 2; complement component receptor 2; complement receptor 1 long isoform; complement receptor 2; complement receptor type 1; complement receptor type 1-like protein; complement receptor type 2; Complement Receptor type 2 (CR2); CR; CR1; Cr-1; CR1-L; Cr2; Cr-2; CVID7; EBV receptor; EBV-R; Epstein-Barr virus receptor; EVBR; expressed in B lymphocytes; KN; Knops blood group antigen; LOW QUALITY PROTEIN: complement receptor type 1; SLEB9
Gene Symbols CR2
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12902, 1380, 289395
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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