CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), Functional Grade, eBioscience™, Invitrogen™

Armenian Hamster Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-2093-050

Product Code. 17141192

Description

The eBio22D1 MAb reacts with mouse SIGNR1 (CD209b). SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase. The eBio22D1 MAb does not cross-react with the closely related SIGNR1, SIGNR2, SIGNR3 or SIGNR4.

CD209b (SIGN-R1) Monoclonal antibody specifically detects CD209b (SIGN-R1) in Mouse samples. It is validated for ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation

Specifications

• Antigen: CD209b (SIGN-R1)
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.2
• Gene Accession No.: Q8CJ91, Q91ZX1
• Host Species: Armenian Hamster
• Quantity: 50 mg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation
• Clone: eBio22D1 (22D1)
• Conjugate: Functional Grade
• Gene: Cd209a
• Gene Alias: 1810030I22Rik; CD209; CD209 antigen-like protein A; CD209 antigen-like protein B; Cd209a; CD209a antigen; CD209a molecule; Cd209b; CD209b antigen; CDSIGN; CIRE; DC SIGNR1; Dcsign; DC-SIGN; DC-SIGN1; DC-SIGNR1; DC-SIGN-related protein 1; Dendritic cell-specific ICAM-3-grabbing non-integrin; MGC130443; mSIGNR1; OtB7; SIGNR1; SIGN-R1; SIGNR5
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170786, 69165
• Content And Storage: 4° C
• Form: Liquid