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Invitrogen™ CD208 (DC-LAMP) Monoclonal Antibody (31B), APC, eBioscience™
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Product Code. 15558056
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25 Tests
Unit Size:
25 tests
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15558056 25 Tests 25 tests
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Product Code. 15558056 Supplier Invitrogen™ Supplier No. 17208941

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Description

Mouse Monoclonal Antibody

Description: This 31B monoclonal antibody reacts with human CD208, which is also known as dendritic cell lysosome-associated membrane glycoprotein (DC-LAMP). CD208 is expressed almost exclusively by mature dendritic cells. Expression of this molecule can be induced in monocytes by stimulation with GM-CSF and IL-4. Moreover, CD208 can be upregulated in CD34+-derived dendritic cells by GM-CSF, SCF, and TNFa. CD208 is also expressed in dendritic cells of non-lymphoid tissues such as skin. While CD208 can be detected on the cell surface, this protein is mainly localized within lysosomes. CD208 plays a key role in the processing and presentation of antigen during the immune response. The 31B antibody only recognizes intracellular CD208, not the cell surface-expressed protein. Applications Reported: This 31B antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This 31B antibody has been pre-titrated and tested by flow cytometric analysis of in vitro differentiated mature dendritic cells. This can be used at 5 μL (0.5 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered.

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).
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Specifications

Antigen CD208 (DC-LAMP)
Applications Flow Cytometry
Classification Monoclonal
Clone 31B
Concentration 5 μL/Test
Conjugate APC
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene LAMP3
Gene Accession No. Q9UQV4
Gene Alias 1200002D17Rik; CD208; DC LAMP; DCLAMP; DC-LAMP; DC-lysosome-associated membrane glycoprotein; dendritic cells-lysosome associated membrane glycoprotein; LAMP; Lamp3; LAMP-3; lysosomal associated membrane protein 3; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; Protein TSC403; TSC403
Gene Symbols LAMP3
Host Species Mouse
Purification Method Affinity chromatography
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27074
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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