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CD200 Receptor Rat anti-Mouse, PE, Clone: OX110, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-5201-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15218799

  • £54.42 / 25µg


Estimated Shipment date
from Supplier 27-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody OX110 recognizes mouse CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNF alpha secretion.

Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells.
Specifications

Specifications

CD200 Receptor
OX110
PE
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
0.2mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
CD200R, OX2R
IgG2a
RUO
Primary
Murine