CD200 Receptor Mouse anti-Human, Clone: OX108, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-9201-85

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15248827

Quantity Price
1 £ 121.67 / 500µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Host Species Murine
Concentration 1mg/mL
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Species Reactivity Human
Format Purified
Isotype IgG1
Primary or Secondary Primary
Quantity 500μg
Clone OX108
Antigen CD200 Receptor
Formulation aqueous buffer, no sodium azide
Conjugate Unlabeled

The monoclonal antibody OX108 recognizes human CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFα secretion. Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs.

Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. The epitope of OX108 is thought to be near the binding site of CD200.