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CD200 Receptor, Functional Grade, clone: OX108, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-9201-85

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15248827

  • £125.34 / 500µg


Estimated Shipment
26-02-2018
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Disclaimers:

For Research Use Only.


Description

Description

Description: The monoclonal antibody OX108 recognizes human CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFalpha secretion. Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs. Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. The epitope of OX108 is thought to be near the binding site of CD200.Applications Reported: This OX108 antibody has been reported for use in flow cytometric analysis and functional assays.Applications Tested: This OX108 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay.Filtration: 0.2μm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.
Specifications

Specifications

CD200 Receptor
OX108
Unconjugated
Purified
IgG1
RUO
Primary
Human
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
Murine
500μg
Store at 2-8°C.
Monoclonal
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