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Invitrogen™ CD200 Polyclonal Antibody, Invitrogen™

Product Code. p-200020060
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Quantity:
20 μL
200 μL
Unit Size:
200µL
20µL
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Product Code. Quantity unitSize
17918842 20 μL 20µL
17929512 200 μL 200µL
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Product Code. 17918842 Supplier Invitrogen™ Supplier No. PA5145284

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Description

Rabbit Polyclonal Antibody

CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD200
Applications Immunohistochemistry (Paraffin), Western Blot, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
Gene Cd200
Gene Accession No. O54901, P41217
Gene Alias antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); Cspmo2; hypothetical protein LOC534910; MOX1; MOX2; MRC; MRC OX-2 antigen; MRCOX2; My033; OX2; OX-2; OX-2 membrane glycoprotein
Gene Symbols Cd200
Host Species Rabbit
Immunogen Recombinant Human CD200 protein, Gln31-Gly232 (Accession #P41217).
Purification Method Antigen affinity chromatography, Protein A
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17470, 4345
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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