Invitrogen™ CD200 Monoclonal Antibody (OX-2), Biotin

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15318470	Invitrogen™ MA517563	100 μg
15328470	Invitrogen™ MA517564	500 μg

Description

CD200 Monoclonal Antibody for Flow

CD200 is a type-1 membrane glycoprotein in the immunoglobulin superfamily, featuring two immunoglobulin domains. It is widely expressed on various cells, including B and T cells, keratinocytes, nerve cells, follicular dendritic cells, ovarian cells, and trophoblasts. CD200 interacts with CD200R on myeloid cells, inhibiting macrophage activation, reducing IL-6 production, and attenuating lymphocyte activation. It also prevents mast cell degranulation and decreases TNF-alpha and IL-13 secretion, playing a role in immune regulation and maternal tolerance. Homologues of CD200 are found in herpesviruses and poxviruses, indicating a conserved immune modulation function. CD200 has multiple alternatively spliced transcript variants, contributing to its functional diversity. Diseases linked to CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy, highlighting its importance in health and disease.

Specifications

• Antigen: CD200
• Concentration: 0.1 mg/mL
• Applications: Flow Cytometry
• Conjugate: Biotin
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with 4-5mg/mL BSA and 0.02% sodium azide
• Gene Accession No.: P04218
• Gene ID (Entrez): 24560
• Immunogen: Rat thymocyte membrane glycoproteins were fused with mouse NS-1 myeloma cells.
• Product Type: Antibody

• Clone: OX-2
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG1
• Target Species: Rat
• Gene: Cd200
• Gene Alias: antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2); Cspmo2; hypothetical protein LOC534910; MOX1; MOX2; MRC; MRC OX-2 antigen; MRCOX2; My033; OX2; OX-2; OX-2 membrane glycoprotein
• Gene Symbols: Cd200
• Primary or Secondary: Primary
• Purification Method: Protein G