CD185 (CXCR5) Mouse anti-Human, Clone: MU5UBEE, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9185-82

Code: Z1

Additional Details:
Additional Details: Weight: 0.00100kg



Disclaimers: For Research Use Only.

Product Code. 15498224

Quantity Price
1 £ 152.25 / 100µg
Estimated Shipment date
from Supplier 02-03-2017
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Description and Specification

Specification

Species Reactivity Human, Non-human primate, Rhesus Ma
Isotype IgG2b
Primary or Secondary Primary
Quantity 100μg
Host Species Mouse
Clone MU5UBEE
Format Purified
Regulatory Status RUO
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Storage Requirements Store at 2-8°C.
Antigen CD185 (CXCR5)
Concentration 0.5mg/mL

The MU5UBEE monoclonal antibody reacts with Mouse CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. In peripheral blood, CXCR5 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells. CXCR5+ circulating T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L. In tonsil, CXCR5 is expressed on nearly all CD4+ cells along with CD45RO and such activation markers as CD69 and ICOS. Tonsillar CXCR5+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CXCR5 an established marker of follicular helper T cells.