CD184 (CXCR4) Mouse anti-Human, PE-Cy5, Clone: 12G5, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 15-9999-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15587766

Quantity Price
1 £ 84.99 / 25 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Regulatory Status RUO
Applications Flow Cytometry
Clone 12G5
Monoclonal or Polyclonal Monoclonal
Host Species Mouse
Quantity 25 tests
Concentration 5μL (0.5μg)/test
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate PE-Cy5
Primary or Secondary Primary
Gene Alias Fusin
Isotype IgG2a
Antigen CD184 (CXCR4)
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.