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CD184 (CXCR4) Mouse anti-Human, APC, Clone: 12G5, eBioscience™

Mouse Monoclonal Antibody

£91.75 - £197.00

Specifications

Antigen CD184 (CXCR4)
Clone 12G5
Target Species Human
Conjugate APC
Isotype IgG2a, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15588296 View Documents Affymetrix eBioscience
17-9999-41
25 Tests £91.75
25 tests View alternative products
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15598296 View Documents Affymetrix eBioscience
17-9999-42
100 Tests £197.00
100 tests View alternative products
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»
EU Stock 3 Please to purchase this item. Need a web account? Register with us today!
Description

Description

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
Specifications

Specifications

CD184 (CXCR4)
Human
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
12G5
APC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.