CD183 (CXCR3) Armenian Hamster anti-Mouse, Clone: CXCR3-173, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1831-81

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15248587

Quantity Price
1 £ 103.33 / 50µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Applications Flow Cytometry
Applications Functional Assay
Antigen CD183 (CXCR3)
Format Purified
Quantity 50μg
Clone CXCR3-173
Isotype IgG
Regulatory Status RUO
Concentration 1mg/mL
Gene Alias C-X-C chemokine receptor type 3, IP-10 receptor
Conjugate Unlabeled
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Primary or Secondary Primary
Host Species Armenian Hamster
Storage Requirements Store at 2-8°C.
Species Reactivity Mouse

The monoclonal antibody CXCR3-173 recognizes mouse CD183 also known as CXCR3. CD183 is a seven transmembrane G-protein liked chemokine receptor which binds three ligands; CXCL9 (mig), CXCL10 (IP-10)and CXCL11 (ITAC). CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-polarized cells.

The antibody CXCR3-173 has been shown to affect chemotaxis in response to ligand. The presence of ligand eliminates staining with the antibody. In vivo addition of the antibody delays cardiac and pancreatic islet allograft rejection.