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CD183 (CXCR3) Armenian Hamster anti-Mouse, Clone: CXCR3-173, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

Brand:  Affymetrix eBioscience 16-1831-81

Code : Z2

Additional Details : Weight : 0.01000kg

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Product Code. 15248587

  • £103.33 / 50µg


Estimated Shipment
29-11-2017
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Disclaimers:

For Research Use Only.


Description

Description

The monoclonal antibody CXCR3-173 recognizes mouse CD183 also known as CXCR3. CD183 is a seven transmembrane G-protein liked chemokine receptor which binds three ligands; CXCL9 (mig), CXCL10 (IP-10)and CXCL11 (ITAC). CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-polarized cells.

The antibody CXCR3-173 has been shown to affect chemotaxis in response to ligand. The presence of ligand eliminates staining with the antibody. In vivo addition of the antibody delays cardiac and pancreatic islet allograft rejection.
Specifications

Specifications

CD183 (CXCR3)
CXCR3-173
Unconjugated
Purified
Armenian Hamster
50μg
Store at 2-8°C.
Monoclonal
Functional Assay
1mg/mL
aqueous buffer, no sodium azide
C-X-C chemokine receptor type 3, IP-10 receptor
IgG
RUO
Primary
Murine