Invitrogen™ CD180 Monoclonal Antibody (RP/14)

Rat Monoclonal Antibody

Brand:  Invitrogen™ MA140034

Product Code. 11549662

Description

MA1-40034 detects CD180 from mouse samples. MA1-40034 has been successfully used in flow cytometry and funtional applications. The MA1-40034 immunogen is mouse RP105/CD180. Endotoxin level < 24 EU/mg.

CD180 (RP105, Bgp95, LY64) is a type I membrane glycoprotein of Toll-like receptor (TLR) family. CD180 cytoplasmic tail is short and unlike the TLRs, it lacks the TIR domain. CD180 expression is dependent on the coexpression of its helper molecule, MD-1, and mirrors that of TLR4 on antigen-presenting cells. CD180 regulates recognition of LPS and signaling in B cells, via interacting directly with the TLR4 signaling complex, inhibiting its ability to bind microbial ligands. Ligation of CD180 by monoclonal antibodies leads to B cell activation, upregulation of CD80/CD86, and increase in cell size. CD180 consists of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is part of the cell surface receptor complex, RP105/MD-1. Diseases associated with CD180 dysfunction include Kawasaki Disease in children and may play a role in rheumatic disease pathology.

Specifications

• Antigen: CD180
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.1% BSA and no preservative
• Gene Accession No.: Q62192
• Gene Symbols: Cd180
• Immunogen: Murine RP105/CD180.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Functional Assay
• Clone: RP/14
• Conjugate: Unconjugated
• Gene: Cd180
• Gene Alias: CD180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; radioprotective 105 kDa protein; RP105
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 17079
• Content And Storage: 4°C
• Form: Liquid