CD161 Mouse anti-Human, PE, Clone: DX12, BD

Mouse Monoclonal Antibody

Product Code	Brand	Quantity
15895908	BD Biosciences 340530	50 Tests
15818638	BD Biosciences 556081	100 Tests

Description

The DX12 monoclonal antibody specifically binds to human CD161 which is also known as Natural killer cell surface protein P1A (NKR-P1A). CD161 is encoded by the KLRB1 (Killer cell lectin-like receptor subfamily B member 1) gene. CD161 is a member of the C-type lectin superfamily and is also referred to as C-type lectin domain family 5 member B (CLEC5B). CD161 is a 80 kDa disulfide-linked homodimer, type II membrane glycoprotein. CD161 is expressed mostly on NK cell populations and on subsets of CD4+ and CD8+ αβ T cells, NKT cells and γδ T cells. Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells. Its function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets. The DX12 antibody can reportedly inhibit spontaneous cytotoxicity mediated by certain NK cell clones.

Specifications

• Antigen: CD161
• Applications: Flow Cytometry
• Conjugate: PE
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG1 κ

• Clone: DX12
• Classification: Monoclonal
• Host Species: Mouse
• Research Discipline: Immunology
• Immunogen: Human NKR-P1A Transfected Mouse Fibroblasts
• Primary or Secondary: Primary

For Research Use Only.