CD160 Rat anti-Mouse, Clone: eBioCNX46-3 (CNX46-3), Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1601-81


UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg

Disclaimers: For Research Use Only.

Product Code. 15278577

Quantity Price
1 £95.00 / 50µg
Estimated Shipment date
from Supplier 27-10-2016
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Description and Specification


Antigen CD160
Applications Flow Cytometry
Applications Functional Assay
Applications Immunoprecipitation
Applications Western Blotting
Clone eBioCNX46-3 (CNX46-3)
Concentration 1mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, no sodium azide
Gene Alias BY55
Host Species Rat
Isotype IgG2a
Quantity 50μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCRγδ T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160). In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus.