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  6. Invitrogen™ CD160 Monoclonal Antibody (eBioCNX46-3 (CNX46-3)), eBioscience™, Invitrogen™

Invitrogen™ CD160 Monoclonal Antibody (eBioCNX46-3 (CNX46-3)), eBioscience™, Invitrogen™

Product Code. 15207267
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500 μg
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Product Code. 15207267 Supplier Invitrogen™ Supplier No. 14160181

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Description

Rat Monoclonal Antibody

Description: CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCRgammadelta T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160). In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus. Applications Reported: This eBioCNX46-3 (CNX46-3) antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunoblotting (WB). (Please use Functional Grade purified eBioCNX46-3 (CNX46-3), cat. 16-1601, in functional assays.). Applications Tested: This eBioCNX46-3 (CNX46-3) antibody has been tested by flow cytometric analysis of C57Bl/6 mouse splenocytes. This can be used at less than or equal to 1 μg per test.

CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. It is involved in cell proliferation, cell surface receptor signaling pathways, cellular defense response, and regulation of immune response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD160
Applications Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone eBioCNX46-3 (CNX46-3)
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene CD160
Gene Accession No. O88875
Gene Alias AU045688; BY55; CD160; CD160 antigen; CD160 antigen, soluble form; CD160 molecule; CD160 transmembrane isoform; CD160-delta Ig; natural killer cell BY55; natural killer cell receptor; natural killer cell receptor BY55; natural killer cell receptor, immunoglobulin superfamily member; NK1; NK28; RGD1563598
Gene Symbols CD160
Host Species Rat
Purification Method Affinity Chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54215
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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