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CD16 Mouse anti-Human, PE, Clone: eBioCB16 (CB16), eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-0168-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15586716

  • £60.53 / 25 tests


Estimated Shipment date
from Supplier 30-06-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

The eBioCB16 monoclonal antibody recognizes CD16 (Fc gammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (Fc gammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
Description & Specifications

Specifications

CD16
eBioCB16 (CB16)
PE
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry
5μL (0.06μg)/test
Conjugated
Low Affinity IgG Receptor 3, FCGR3a, FCGR3, IGFR5
IgG1
RUO
Primary
Human