CD16 Mouse anti-Human, eVolve 605, Clone: eBioCB16 (CB16), eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 83-0168-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15540747

Quantity Price
1 £ 84.99 / 25 tests
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Concentration 5μL
Conjugate eVolve 605
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Format Conjugated
Isotype IgG1
Gene Alias Low Affinity IgG Receptor 3, FCGR3a, IGFR4
Antigen CD16
Applications Flow Cytometry
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This product should be used within 6 months from the date of receipt.
Quantity 25 tests
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human
Primary or Secondary Primary
Host Species Mouse
Clone eBioCB16 (CB16)

The eBioCB16 monoclonal antibody recognizes CD16 (Fc gamma RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (Fc gamma RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gamma RIIIB), which exists as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation, and proliferation.