CD158f Mouse anti-Human, PE, Clone: UP-R1, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1588-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15586906

Quantity Price
1 £ 195.05 / 100 tests
Estimated Shipment date
from Supplier 05-04-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Conjugate PE
Gene Alias KIR2DL5/S5, KIR
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen CD158f
Format Conjugated
Isotype IgG1
Quantity 100 tests
Concentration 5μL (0.25μg)/test
Clone UP-R1
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry
Regulatory Status RUO

This UP-R1 monoclonal antibody recognizes human CD158f, also known as KIR2DL5. CD158f is an inhibitory receptor and a member of the KIR (Killer cell Ig-like receptors) family of receptors, which recognizes subsets of HLA alleles. Expression is found mainly on a subset of NK cells with minimal expression also present on a minor subset of T lymphocytes in some individuals. This new member of the family is highly polymorphic and expression is not found on many human donors. Activation of the receptor and tyrosine phosphoryaltion recruits SHP-2 and SHP-1 to the ITIM cytoplasmic domain.

The UP-R1 antibody has been shown to inhibit NK cytotoxicity.