Invitrogen™ CD156A/EGFR Biosimilar Recombinant Human Monoclonal Antibody

Human Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA560144

Product Code. 30284380

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.

The CD156A gene, also known as ADAM8 (a disintegrin and metalloprotease 8), is a cell surface antigen highly expressed in monocytic lineages, with a significant role in neurodegenerative diseases and cancer. It is a membrane-anchored metalloprotease with a long extracellular region containing domains similar to hemorrhagic snake venom proteins. ADAM8 is involved in the regulation of cell adhesion and proteolysis. The gene encoding CD156A is located on human chromosome 10q26.3. Meanwhile, the EGFR gene, or epidermal growth factor receptor, is part of the ErbB family of receptor tyrosine kinases located on chromosome 7p11.2. EGFR plays a crucial role in regulating cell proliferation, differentiation, survival, and migration. It is a 170-kDa transmembrane glycoprotein and is heavily implicated in various cancers, including non-small-cell lung cancer and glioblastoma due to mutations or overexpressions. Both genes are critical for cell communication and regulation processes, with significant implications for cancer therapy and neurodegenerative disease research.

Specifications

• Antigen: CD156A/EGFR Biosimilar
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Host Species: Human
• Quantity: 1 mg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: ELISA, Flow Cytometry, Functional Assay
• Concentration: 1 mg/mL
• Formulation: 25mM histidine with 8% sucrose, 0.01% Tween 80 and no preservative; pH 6.2
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1