Invitrogen™ CD153 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA536365

Product Code. 15557641

Description

This antibody detects endogenous protein at a molecular weight of 26 kDa. Purity is >95% by SDS-PAGE.

The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that coexpress CD45RO and the IL4 receptor.

Specifications

• Antigen: CD153
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tnfsf8
• Gene Alias: CD153; CD153 antigen; CD30 antigen ligand; CD30 ligand; Cd30l; CD30-L; Cd30lg; CD30ligand; Tnfsf8; TNLG3A; tumor necrosis factor (ligand) superfamily member 8; tumor necrosis factor (ligand) superfamily, member 8; tumor necrosis factor ligand 3A; tumor necrosis factor ligand superfamily member 8; tumor necrosis factor superfamily member 8
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21949, 683163, 944
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P32971, P32972
• Gene Symbols: Tnfsf8
• Immunogen: Synthetic peptide corresponding to amino acids 80-130 of human CD30-L.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG