CD152 (CTLA-4) Mouse anti-Human, PE, Clone: 14D3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1529-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15526906

Quantity Price
1 £ 149.04 / 100 tests
EU Stock 19
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Description and Specification

Specification

Quantity 100 Tests
Host Species Murine
Species Reactivity Human, Rhesus Ma
Antigen CD152 (CTLA-4)
Monoclonal or Polyclonal Monoclonal
Regulatory Status RUO
Applications Flow Cytometry
Isotype IgG2a
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone 14D3
Concentration 5μL (0.03μg)/test
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Conjugate PE

The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.

The 14D3 antibody also recognizes rhesus monkey and has inhibitor activity.