CD152 (CTLA-4) Golden Syrian Hamster anti-Mouse, Clone: 9H10, Functional Grade, eBioscience™

Golden Syrian Hamster Monoclonal Antibody, Functional Grade

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 16-1521-82

100UG:ANTI-MOUSE CD152(CTLA-4)FUNCTIONAL GRADE

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15288567

Quantity Price
1 £ 126.0 / 100µg
Estimated Shipment date
from Supplier 13-12-2016
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Description and Specification

Specification

Antigen CD152 (CTLA-4)
Applications Flow Cytometry
Applications Functional Assay
Clone 9H10
Concentration 1mg/mL
Conjugate Unlabeled
Format Purified
Formulation aqueous buffer, no sodium azide
Gene Alias CTLA4
Host Species Golden Syrian Hamster
Isotype IgG
Quantity 100μg
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The 9H10 monoclonal antibody reacts with mouse CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in a large proportion of newly synthesized CTLA-4 in response to TCR signaling to be localized intracellularly.