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  6. CD150 (SLAM) Hamster, anti-Mouse, Alexa Fluor 488, Clone: TC15-12F12.2, STEMCELL Technologies

CD150 (SLAM) Hamster, anti-Mouse, Alexa Fluor 488, Clone: TC15-12F12.2, STEMCELL Technologies

Product Code. 17118681
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25 μg
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17118681 100 μg 100µg
17128681 25 μg 25µg
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Product Code. 17118681 Supplier Stemcell Technologies Supplier No. 60036AD

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Description

Hamster Monoclonal Antibody

  • The TC15-12F12
  • 2 antibody reacts with CD150 (signaling lymphocyte activation molecule or SLAM), an ∼75 kDa type I transmembrane glycoprotein that plays multiple roles in the immune response by serving as a cell adhesion molecule and/or coreceptor
  • It is differentially expressed by T cells, immature thymocytes, B cells, dendritic cells, macrophages, and endothelial cells
  • The expression pattern differs according to cell type and activation status
  • Expression is rapidly induced upon activation of T cells, B cells and dendritic cells, with synthesis by T cells being maintained on Th1 but not Th2 clones
  • CD150-mediated co-stimulation of TCR-activated T cells enhances the production of IFN-γ by Th1 cells, a response that can be augmented by binding of the TC15-12F12
  • 2 antibody
  • CD150 is thought to mediate signal transduction by associating with the intracellular protein tyrosine phosphatase, SHP-2

Specifications

Antigen CD150 (SLAM)
Applications Immunohistochemistry, Flow Cytometry, Immunofluorescence, Functional Assay, Immunoprecipitation
Classification Monoclonal
Clone TC15-12F12.2
Conjugate Alexa Fluor 488
Host Species Hamster
Quantity 100 μg
Primary or Secondary Primary
Target Species Mouse
Isotype IgG2a λ
Cell Type Hematopoietic Stem and Progenitor Cells
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