CD144 (VE-Cadherin) Rat anti-Mouse, Clone: eBioBV14 (BV14), eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-1442-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15207237

Quantity Price
1 £ 91.11 / 100µg
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Species Reactivity Mouse
Monoclonal or Polyclonal Monoclonal
Conjugate Unlabeled
Concentration 0.5mg/mL
Quantity 100μg
Format Purified
Primary or Secondary Primary
Host Species Rat
Storage Requirements Store at 2-8°C.
Clone eBioBV14 (BV14)
Gene Alias Cadherin 5
Antigen CD144 (VE-Cadherin)
Isotype IgG2b
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The BV14 monoclonal antibody reacts with mouse VE-Cadherin (CD144). VE-Cadherin is a 120kDa member of the type II Cadherin family, characterized by the presence of 5 extracellular cadherin domains (ECD), and anchored to the actin cytoskeleton through their cytoplasmic tail. VE-Cadherin mediates homophilic adhesion between neighbouring endothelial cells and is localized within specialized structures at cell-cell contacts, called adherens junctions. VE-Cadherin is expressed constitutively throughout the entire vasculature, and is required for numerous endothelial cell functions including migration, survival, contact-dependent growth inhibition and endothelial cell assembly into tubular structures. Furthermore, it is thought that VE-Cadherin+CD45- cells from the yolk sac or aorta-gonad-mesonephros (AGM)+ have the potential to give rise to hematopoietic cells. Cross-blocking experiments suggest that BV14 recognizes a different epitope than another mouse VE-Cadherin monoclonal antibody, BV13.