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CD137 Polyclonal Antibody, PeproTech®, Invitrogen™

Goat Polyclonal Antibody

Brand:  Invitrogen 500-P167G-50UG

Additional Details : Weight : 0.16500kg

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Product Code. 17834413

  • £165.00 / 50µg
Estimated Shipment: 09-08-2024
to see stock.

Description

Description

AA Sequence of recombinant protein: MERTRSLQDP CSNCPAGTFC DNNRNQICSP CPPNSFSSAG GQRTCDICRQ CKGVFRTRKE CSSTSNAECD CTPGFHCLGA GCSMCEQDCK QGQELTKKGC KNCCFGTFND QKRGICRPWT NCSLDGKSVL VNGTKERDVV CGPSPADLSP GASSVTPPAP AREPGHS. Preparation: Produced from sera of goats immunized with highly pure Recombinant Human 4-1BB Receptor. Anti-Human 4-1BB Receptor-specific antibody was purified by affinity chromatography employing an immobilized Human 4-1BB Receptor matrix. Sandwich ELISA: To detect Human 4-1BB Receptor by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human 4-1BB Receptor (500-P167GBt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human 4-1BB Receptor. Western Blot: To detect Human 4-1BB Receptor by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human 4-1BB Receptor is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
Specifications

Specifications

CD137
Polyclonal
Unconjugated
TNFRSF9
4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
Goat
Antigen affinity chromatography
RUO
3604
-20°C
ELISA, Western Blot
0.1-1.0 mg/mL
PBS with no preservative
Q07011
TNFRSF9
E.coli-derived Recombinant Human 4-1BB Receptor
50 μg
Primary
Human
Lyophilized
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