CD127 Rat anti-Mouse, Alexa Fluor 700, Clone: A7R34, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 56-1271-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15382130

Quantity Price
1 £ 123.42 / 25µg
EU Stock 1
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Description and Specification

Specification

Gene Alias Interleukin-7 Receptor alpha
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Monoclonal or Polyclonal Monoclonal
Host Species Rat
Primary or Secondary Primary
Species Reactivity Mouse
Isotype IgG2a
Clone A7R34
Antigen CD127
Format Conjugated
Applications Flow Cytometry
Conjugate Alexa Fluor 700
Quantity 25μg
Concentration 0.2mg/mL

The A7R34 monoclonal antibody reacts with mouse CD127, the high affinity alpha subunit of the mouse IL-7 receptor. IL-7 receptor alpha chain is expressed by immature B cells in the bone marrow, double-negative (CD4-CD8-), single-positive (CD4+ and CD8+), but not double-positive (CD4+CD8+) thymocytes. In the periphery, mature T cells express CD127 at low level. A7R34 inhibits binding of IL-7 to its receptor and has been used in in vivo and in vitro studies to elucidate the role of IL-7 in T and B cell development and activation. Binding of A7R34 blocks the binding of SB/199, another antibody which recognizes mouse CD127.