CD11c Mouse anti-Human, eFluor 570, Clone: 118/A5, eBioscience™

Mouse Monoclonal Antibody

Brand:  Invitrogen 41-9761-80

Product Code. 15508966

Description

The monoclonal antibody 118/A5 recognizes human CD11c, a 150 kD type I transmembrane protein which is also known as integrin alpha X. Integrins are heterodimeric integral membrane proteins made up of an alpha and a beta chain and are involved in cell adhesion. The CD11/CD18 adhesion molecules consist of three heterodimers sharing a common beta subunit (CD18) with a distinct alpha subunit (CD11a, CD11b, CD11c). The CD11c/CD18 complex is expressed on dendritic cells (highly expressed on type 1 myeloid DCs), monocytes, macrophages, granulocytes, NK cells, and subsets of T and B cells. CD11c is also expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias. CD11c plays a role in adhesion and CTL killing through its interactions with CD54, iC3b and fibrinogen.

Specifications

• Antigen: CD11c
• Classification: Monoclonal
• Concentration: 0.2mg/mL
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Host Species: Mouse
• Regulatory Status: RUO
• Target Species: Human
• Isotype: IgG2b κ

• Applications: Immunohistochemistry, Immunohistochemistry (Frozen), Immunomicroscopy
• Clone: 118/A5
• Conjugate: eFluor 570
• Gene Alias: Integrin alpha X
• Quantity: 25 μg
• Primary or Secondary: Primary
• Content And Storage: Store at 2-8°C. Do not freeze. Light-sensitive material.

For Research Use Only.