CD11b Mouse, anti-Human, Unconjugated, Clone: ICRF44, STEMCELL Technologies

Mouse Monoclonal Antibody

Brand:  Stemcell Technologies 60040

Product Code. 17108721

Description

• The ICRF44 antibody reacts with an extracellular epitope on CD11b (integrin αM), an ∼170 kDa type 1 transmembrane glycoprotein which associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor
• Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, heparin, and fibrinogen, Mac-1 influences several processes, including the adherence of neutrophils and monocytes to stimulated endothelium, and phagocytosis of complement-coated particles
• CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages, and subsets of T and B cells, and has been used as a marker to distinguish naive and memory CD8+ T cells
• This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human Monocyte Enrichment Kit (Catalog #19059), and for labeling human mesenchymal cells grown in MesenCult™ Proliferation Kit (Human; Catalog #05411)

Specifications

• Antigen: CD11b
• Classification: Monoclonal
• Conjugate: Unconjugated
• Quantity: 100 μg
• Target Species: Baboon, Cynomolgus, Rhesus Monkey, Chimpanzee, Human
• Cell Type: Myeloid Cells

• Applications: Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Clone: ICRF44
• Host Species: Mouse
• Primary or Secondary: Primary
• Isotype: IgG1 κ