CD117 (c-Kit) Rat, anti-Mouse, Unconjugated, Clone: ACK2, STEMCELL Technologies

Rat Monoclonal Antibody

Brand:  Stemcell Technologies 60034

Product Code. 17138661

Description

• The ACK2 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells
• CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
• Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
• Signaling by CD117 is modulated by phosphatases and by rapid endocytosis and degradation of the receptor
• Mutations in CD117 are associated with various types of tumors and the piebald trait, an autosomal dominant abnormality of pigmentation

Specifications

• Antigen: CD117 (c-Kit)
• Classification: Monoclonal
• Conjugate: Unconjugated
• Quantity: 500 μg
• Target Species: Mouse
• Cell Type: Hematopoietic Stem and Progenitor Cells

• Applications: Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Clone: ACK2
• Host Species: Rat
• Primary or Secondary: Primary
• Isotype: IgG2b κ