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CD117 (c-Kit) Rat, anti-Mouse, APC, Clone: ACK2, STEMCELL Technologies
Rat Monoclonal Antibody
£153.90 - £355.05
Specifications
| Antigen | CD117 (c-Kit) |
|---|---|
| Clone | ACK2 |
| Applications | Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence |
| Classification | Monoclonal |
| Conjugate | APC |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17178661
|
Stemcell Technologies
60034AZ.1 |
25 μg |
£153.90
25µg |
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|
17168661
|
Stemcell Technologies
60034AZ |
100 μg |
£355.05
100µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- The ACK2 antibody reacts with CD117 (c-Kit), an ∼145 kDa type 1 transmembrane receptor for c-Kit ligand (stem cell factor/steel factor) that is broadly expressed on hematopoietic stem cells in bone marrow, including pluripotent and erythroid progenitor cells and B and T lymphocyte precursors, as well as on mast cells
- CD117 belongs to the tyrosine kinase receptor family and possesses five immunoglobulin-like C2-type domains and a cytoplasmic protein kinase domain
- Binding of c-Kit ligand to CD117 induces dimerization and autophosphorylation, which activates several intracellular signaling pathways critical for the proliferation and differentiation of hematopoietic stem cells
- Signaling by CD117 is modulated by phosphatases and by rapid endocytosis and degradation of the receptor
- Mutations in CD117 are associated with various types of tumors and the piebald trait, an autosomal dominant abnormality of pigmentation
Specifications
| CD117 (c-Kit) | |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| APC | |
| Mouse | |
| Primary |
| ACK2 | |
| Monoclonal | |
| Rat | |
| IgG2b κ |
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