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CD105 (Endoglin) Mouse, anti-Human, Biotin, Clone: 43A3, STEMCELL Technologies

Product Code. 17158711
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Quantity:
100 μg
Unit Size:
100µg
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17158711 100 μg 100µg
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Product Code. 17158711 Supplier Stemcell Technologies Supplier No. 60039BT

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Description

Mouse Monoclonal Antibody

  • The 43A3 antibody reacts with CD105 (endoglin), an ∼180 kDa cell surface glycoprotein which is a disulfide-bonded homodimer of ∼90 kDa type I transmembrane subunits
  • CD105 is a component of the TGF-β receptor complex and is expressed by vascular endothelial smooth muscle cells, syncytiotrophoblasts of placenta and activated macrophages, and at relatively low levels by stromal fibroblasts
  • Its expression is also observed in some types of tumors, and levels are up-regulated on the endothelium during angiogenesis
  • CD105 has important roles in angiogenesis, cardiovascular development, and vascular remodeling, and the protein serves a regulatory role in cytoskeletal reorganization by modulating the sites of focal adhesion and cellular migration
  • This antibody clone has been verified for labeling human mesenchymal cells grown in MesenCult™ Proliferation Kit (Human; Catalog #05411) and MesenCult™-XF Medium (Catalog #05420)

Specifications

Antigen CD105 (Endoglin)
Applications Immunoprecipitation, Western Blot, Flow Cytometry
Classification Monoclonal
Clone 43A3
Conjugate Biotin
Host Species Mouse
Quantity 100 μg
Primary or Secondary Primary
Target Species Human, Mouse
Isotype IgG1 κ
Cell Type Hematopoietic Stem and Progenitor Cells, Mesenchymal Stem and Progenitor Cells
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