CD10 Mouse anti-Human, Biotin, Clone: SN5c, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 13-0108-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.25000kg



Disclaimers: For Research Use Only.

Product Code. 15279439

Quantity Price
1 £ 42.19 / 25µg
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Gene Alias Common Acute Lymphocytic Leukemia antigen (CALLA), Neprilysin,
Conjugate Biotin
Storage Requirements Store at 2-8°C. Do not freeze.
Clone SN5c
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry
Applications Immunohistochemistry (Frozen)
Format Conjugated
Host Species Mouse
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Concentration 0.5mg/mL
Quantity 25μg
Antigen CD10
Regulatory Status RUO
Isotype IgG1

The eBioSN5c monoclonal antibody recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALLs). Subsequently, CD10 was shown to be the same molecule as neutral endopeptidase (NEP), or KII-NA. CD10 is a Zn2+-dependent metallopeptidase acting on substrates such as endothelin, glucagon, gastrin, neurotensin and bradykinin. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils. In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and its expression has been reported on mature germinal center B cells. CD10 expression is also found on normal donor granulocytes and bone marrow stromal cells. Most likely, CB-CALLA and eBioSN5c see different epitopes due to their ability to co-stain.