CD10 Monoclonal Antibody (eBioCB-CALLA (CB-CALLA)), eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-0106-95

Product Code. 17150422

Description

The eBioCB-CALLA MAb recognizes human CD10 (CALLA, NEP, enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoprotein originally identified for its expression on most acute lymphoblastic leukemias (ALL). Subsequently, CD10 was shown to be the same molecule as the neutral endopeptidase (NEP), or KII-NA. CD10 is a Zn2+-dependent metallo-peptidase with endothelin, glucagon, gastrin, neurotensin and bradykinin included among its substrates. CD10 is involved in the regulation of chemotactic and inflammatory processes involving neutrophils. In B cells, CD10 regulates stromal cell-dependent B lymphopoiesis and expression has also been reported on mature B cells in germinal centres. In addition to the hematopoietic compartment, other major sites of CD10 expression are the brush border of enterocytes and renal tubules and glomeruli. There is partial blocking of the eBioCB-CALLA and MEM-78 monoclonal antibodies indicating that they recognize similar epitopes.

CD10 Monoclonal antibody specifically detects CD10 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry, Immunofluorescence

Specifications

• Antigen: CD10
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: P08473
• Host Species: Mouse
• Quantity: 10 mg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence
• Clone: eBioCB-CALLA (CB-CALLA)
• Conjugate: Unconjugated
• Gene: Mme
• Gene Alias: 6030454K05Rik; Atriopeptidase; C85356; CALLA; CD10; CMT2T; common acute lymphoblastic leukemia antigen; common acute lymphocytic leukemia antigen; Enkephalinase; EPN; membrane metallo endopeptidase; membrane metalloendopeptidase; membrane metallo-endopeptidase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; MME; NEP; Neprilysin; neprilysin-390; neprilysin-411; Neutral endopeptidase 24.11; SFE; Skin fibroblast elastase
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4311
• Content And Storage: 4° C
• Form: Liquid