Invitrogen™ CCM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA554173

Product Code. 15712111

Description

Immunogen sequence: LHSDDSSTKV DIKETYEVEA STFCFPESVD VGGASPHSKT ISESELSASA TELLQDYMLT LRTKLSSQEI QQFAALLHEY RNGA Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 78%.

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: CCM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCM2
• Gene Alias: BC029157; C7orf22; Ccm2; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformation 2 homolog; cerebral cavernous malformations 2 protein; Cerebral cavernous malformations protein 2 homolog; malcavernin; MGC4067; MGC4607; MGC74868; Oncostatin; OncostatinM; Osm; osmosensing scaffold for MEKK3; PP10187
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 83605
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BSQ5
• Gene Symbols: CCM2
• Immunogen: Recombinant protein corresponding to Human CCM2. Recombinant protein control fragment (Product #RP-92737).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG