Invitrogen™ CCDC8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5103756

Product Code. 16670205

Description

Antibody detects endogenous levels of total CCDC8.

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.

Specifications

• Antigen: CCDC8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCDC8
• Gene Alias: 3M3; CCDC8; coiled-coil domain containing 8; coiled-coil domain containing protein 8; coiled-coil domain-containing protein 8; Coiled-coil domain-containing protein 8 homolog; ENSMUSG00000041117; p90; PPP1R20; probable Coiled-coil domain-containing protein 8; protein phosphatase 1, regulatory subunit 20
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 434130, 83987
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: D3YZV8, Q9H0W5
• Gene Symbols: CCDC8
• Immunogen: A synthesized peptide derived from human CCDC8(Accession Q9H0W5), corresponding to amino acid residues F44-V94.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG