Invitrogen™ CCBL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA554341

Product Code. 15782271

Description

Immunogen sequence: LITDISDFKR KMPDLPGAVD EPYDRRFVKW MIKNKGLVAI PVSIFYSVPH QKHFDHYIRF CFVKDEATLQ AMDEKLRKWK VEL Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 82%.

Kynurenine aminotransferases KAT I, KAT II, and KAT III belong to the class-I pyridoxal-phosphate-dependent aminotransferase family. KAT I is a cytoplasmic protein involved in glutamine catabolism. KAT I functions in the catalysis of the transamination of L-kinurenine to form kynurenic acid, a neuroprotective and anticonvulsant metabolite of tryptophan. Kynurenic acid is involved in synaptic transmission and has been implicated in a number of neurological disorders including schizophrenia and Huntington's disease. KAT I also functions in the metabolism of cysteine conjugates in some halogenated alkenes and alkanes to form reactive metabolites. KAT I has three isoforms. Isoform 1is the full length protein, isoform 2 lacks amino acids 68-117 and isoform 3 lacks amino acids 251-422. Based on sequence similarity, KAT I is thought to function as a homodimer.

Specifications

• Antigen: CCBL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KYAT1
• Gene Alias: 2010009K05Rik; AI182306; beta-lysase, kidney; CCBL1; cysteine conjugate beta lyase 1; cysteine conjugate-beta lyase 1; cysteine conjugate-beta lyase, cytoplasmic; cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); cysteine-S-conjugate beta-lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); glutamine transaminase K; glutamine-phenylpyruvate aminotransferase; Glutamine--phenylpyruvate transaminase; Gtk; Kat; KAT1; KATI; KYAT1; kyneurenine aminotransferase; kynurenine aminotransferase 1; Kynurenine aminotransferase I; kynurenine aminotransferase/glutamine transaminase K; kynurenine--oxoglutarate transaminase 1; Kynurenine--oxoglutarate transaminase 1, mitochondrial; kynurenine--oxoglutarate transaminase I
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 883
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q16773
• Gene Symbols: KYAT1
• Immunogen: Recombinant protein corresponding to Human CCBL1. Recombinant protein control fragment (Product #RP-93062).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG