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CATSPER1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA550372
Additional Details : Weight : 0.01000kg
Description
The antibody detects endogenous levels of total CATSPER1 protein.
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.Specifications
CATSPER1 | |
Polyclonal | |
Unconjugated | |
CATSPER1 | |
cation channel of sperm 1; cation channel sperm associated 1; cation channel sperm-associated protein 1; cation channel, sperm associated 1; CATSPER; CATSPER1; hCatSper; KSper; sperm ion channel; sperm protein CATSPER1; sperm-associated cation channel 1; SPGF7 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
117144 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin) | |
1.8 mg/mL | |
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4 | |
Q8NEC5 | |
CATSPER1 | |
Fusion protein corresponding to residues near the C terminal of human cation channel, sperm associated 1 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |