Invitrogen™ Cathepsin C Polyclonal Antibody

Goat Polyclonal Antibody

Brand:  Invitrogen™ PA547049

Product Code. 15537542

Description

In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Cathepsin C is observed and less than 1% cross-reactivity with recombinant mouse (rm) Cathepsin A, rmCathepsin B, rmCathepsin D, rmCathepsin H, and rmCathepsin X/Z/P is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Cathepsin C, known also as dipeptidyl aminopeptidase I (DPPI), is a tetrameric lysosomal cysteine peptidase belonging to the papain family. Cathepsin C is involved in intracellular protein degradation and the processing of protein precursors, where it participates in cell growth, neuraminidase activation, and platelet factor XIII activation. Cathepsin C is largely related to other lysosomal cysteine proteinases, including cathepsin B, H and L. Enzymatically, Cathepsin C is capable of sequentially removing dipeptides from the amino terminus, and it requires halide ions, namely chloride ions, and thiols for complete enzymatic activity. Protein levels of Cathepsin C are detected in a variety of tissues, and it is most highly expressed in spleen, kidney, cytotoxic lymphocytes and myeloid cells, where it localizes to the secretory granule compartment. Cathepsin C is initially synthesized as a proenzyme that is rapidly processed to generate two distinct chains that function together as the mature form of the enzyme.

Specifications

• Antigen: Cathepsin C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CTSC
• Gene Alias: AI047818; CATC; Cathepsin C; cathepsin J; CPPI; CTSC; Dipeptidyl peptidase 1; Dipeptidyl peptidase 1 exclusion domain chain; Dipeptidyl peptidase 1 heavy chain; Dipeptidyl peptidase 1 light chain; Dipeptidyl peptidase I; Dipeptidyl peptidase I exclusion domain chain; Dipeptidyl peptidase I heavy chain; Dipeptidyl peptidase I light chain; Dipeptidyl transferase; dipeptidyl-peptidase; dipeptidylpeptidase 1; dipeptidyl-peptidase 1; dipeptidyl-peptidase I; DPP1; DPPI; DPP-I; HMS; JP; JPD; PALS; PDON1; PLS
• Host Species: Goat
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13032, 25423
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P80067, P97821
• Gene Symbols: CTSC
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin C/DPPI Asp25-Leu462.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG