Invitrogen™ Cathepsin 1/7 Monoclonal Antibody (228905)

Rat Monoclonal Antibody

Brand:  Invitrogen™ MA560991

Product Code. 30534991

Description

Reconstitute at 0.5 mg/mL in sterile PBS.

Cathepsins are a family of proteases, and Cathepsins B and L (sometimes referred to as Cathepsin 1 and Cathepsin 7, respectively) are notable members of this group. These enzymes are primarily involved in the degradation of proteins within lysosomes, contributing to cellular turnover and homeostasis. Cathepsin B, encoded by the CTSB gene, is a cysteine protease that participates in various physiological processes, including protein catabolism, antigen processing, and apoptosis. Similarly, Cathepsin L, encoded by the CTSL gene, also functions as a cysteine protease and is crucial for normal cellular functions, such as tissue remodeling and immune responses. Dysregulation of these enzymes has been implicated in numerous pathological conditions, including cancer, neurodegenerative diseases, and inflammatory disorders. Understanding the roles and regulation of Cathepsin B and Cathepsin L can provide valuable insights into disease mechanisms and potential therapeutic interventions.

Specifications

• Antigen: Cathepsin 1/7
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with trehalose and no preservative
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin 7/Cathepsin 1, Ala18-Leu331.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Lyophilized

• Applications: Immunoprecipitation, Western Blot
• Clone: 228905
• Conjugate: Unconjugated
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a