Invitrogen™ Caspase 7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA595241

Product Code. 16394505

Description

Human Caspase-7 shares 92.7% amino acid (aa) sequence identity with both mouse and rat Caspase-7. Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: A549 whole cell, Rat Spleen Tissue, Rat Lung Tissue. IHC: Human Mammary Cancer Tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.

Specifications

• Antigen: Caspase 7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP7
• Gene Alias: AI314680; Apoptotic protease Mch-3; Casp7; CASP-7; caspase 7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; cysteine protease LICE2; ICE-IAP3; ICE-LAP3; ICE-like apoptotic protease 3; Lice2; mCASP-7; MCH3; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64026, 840
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and no preservative
• Gene Accession No.: P55210
• Gene Symbols: CASP7
• Immunogen: E.coli-derived human Caspase-7 recombinant protein (Position: A117-D198).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG