Invitrogen™ Caspase 5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5111126

Product Code. 17179043

Description

Immunogen sequence: VEGVFIFLIE DSGKKKRRKN FEAMFKGILQ SGLDNFVINH MLKNNVAGQT SIQTLVPNTD QKSTSVKKDN HKKKTVKMLE YLGKDV Highest antigen sequence indentity to the following orthologs: Mouse - 23%, Rat - 23%.

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1-b and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1-b. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.

Specifications

• Antigen: Caspase 5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP5
• Gene Alias: CASP5; CASP-5; caspase 5; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; caspase-5; Caspase-5 subunit p10; Caspase-5 subunit p20; ICE(rel)III; ICE(rel)-III; ICEREL-III; ICH3; ICH-3; Protease ICH-3; protease TY; TY protease
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 838
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P51878
• Gene Symbols: CASP5
• Immunogen: Recombinant Protein corresonding to Human Caspase 5. Recombinant protein control fragment (Product #RP-98453).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG